Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation
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چکیده
منابع مشابه
Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation
We performed inhalation and intratracheal instillation studies of cerium dioxide (CeO2) nanoparticles in order to investigate their pulmonary toxicity, and observed pulmonary inflammation not only in the acute and but also in the chronic phases. In the intratracheal instillation study, F344 rats were exposed to 0.2 mg or 1 mg of CeO2 nanoparticles. Cell analysis and chemokines in bronchoalveola...
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In order to investigate the pulmonary toxicity of titanium dioxide (TiO2) nanoparticles, we performed an intratracheal instillation study with rats of well-dispersed TiO2 nanoparticles and examined the pulmonary inflammation and histopathological changes in the lung. Wistar Hannover rats were intratracheally administered 0.2 mg (0.66 mg/kg) and 1.0 mg (3.3 mg/kg) of well-dispersed TiO2 nanopart...
متن کاملEvaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation
We conducted inhalation and intratracheal instillation studies of zinc oxide (ZnO) nanoparticles in order to examine their pulmonary toxicity. F344 rats were received intratracheal instillation at 0.2 or 1 mg of ZnO nanoparticles with a primary diameter of 35 nm that were well-dispersed in distilled water. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed at thre...
متن کاملIntratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
BACKGROUND Cerium oxide (CeO(2)) nanoparticles have been posited to have both beneficial and toxic effects on biological systems. Herein, we examine if a single intratracheal instillation of CeO(2) nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats. METHODS AND RESULTS Compared with control animals, CeO(2) nanoparticle exposure was associated with increased liver c...
متن کاملThe acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice
Cerium oxide nanoparticles (CeO2 NPs), used as a diesel fuel catalyst, can be emitted into the ambient air, resulting in exposure to humans by inhalation. Recent studies have reported the development of lung toxicity after pulmonary exposure to CeO2 NPs. However, little is known about the possible thrombotic effects of these NPs. The present study investigated the acute (24 hours) effect of int...
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ژورنال
عنوان ژورنال: Journal of Nanoparticle Research
سال: 2015
ISSN: 1388-0764,1572-896X
DOI: 10.1007/s11051-015-3249-1